Born in Moscow. In 2004 Natalia graduated from the Moscow State Academy of choreography (class of Marina Leonova) and joined the Bolshoi Theatre ballet company (Moscow). Natalia took part in the Bolshoi theatre tours, having performed at the world leading ballet venues. She won Grand Prix at Prix de Luxembourg International Ballet Competition (2003). In 2007, Osipova was awarded Soul of Dance Prize in the category «Rising Star» from Ballet Magazine. In 2009, (together with Vyacheslav Lopatin) she was awarded the Special Prize of the Golden Mask jury — for best duet in La Sylphide (2007/8 season).